Sepp-Lorenzino Sepp-Lorenzino: search on Z-Library

The world's largest scientific articles store. 70,000,000+ articles for free.

Don't use scam websites

1

Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles

Randy Crawford, Belma Dogdas, Edward Keough, R. Matthew Haas, Wickliffe Wepukhulu, Steven Krotzer, Paul A. Burke, Laura Sepp-Lorenzino, Ansuman Bagchi, Bonnie J. Howell

Journal:

International Journal of Pharmaceutics

Year:

2011

Language:

english

File:

PDF, 1.80 MB

english, 2011

2

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

Gabriela Chiosis, Merna N Timaul, Brian Lucas, Pamela N Munster, Fuzhong F Zheng, Laura Sepp-Lorenzino, Neal Rosen

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 931 KB

english, 2001

3

Novel Endosomolytic Poly(amido amine) Polymer Conjugates for Systemic Delivery of siRNA to Hepatocytes in Rodents and Nonhuman Primates

Parmar, Rubina Giare, Poslusney, Micheal, Busuek, Marina, Williams, J. Michael, Garbaccio, Robert, Leander, Karen, Walsh, Eileen, Howell, Bonnie, Sepp-Lorenzino, Laura, Riley, Sean, Patel, Mihir, Kemp

Journal:

Bioconjugate Chemistry

Year:

2014

Language:

english

File:

PDF, 1.22 MB

english, 2014

4

ChemInform Abstract: Total Synthesis of Tryprostatin B: Generation of a Nucleophilic Prenylating Species from a Prenylstannane.

K. M. DEPEW, S. J. DANISHEFSKY, N. ROSEN, L. SEPP-LORENZINO

Journal:

Year:

1997

File:

PDF, 33 KB

1997

5

ChemInform Abstract: A Concise Total Synthesis of Dysidiolide Through Application of a Dioxolenium-Mediated Diels—Alder Reaction.

S. R. MAGNUSON, L. SEPP-LORENZINO, N. ROSEN, S. J. DANISHEFSKY

Journal:

Year:

1998

File:

PDF, 36 KB

1998

6

ChemInform Abstract: Total Synthesis of Spirotryprostatin A, Leading to the Discovery of Some Biologically Promising Analogues.

Scott Edmondson, Samuel J. Danishefsky, Laura Sepp-Lorenzino, Neal Rosen

Journal:

Year:

1999

File:

PDF, 27 KB

1999

7

ChemInform Abstract: Synthesis and Evaluation of Geldanamycin-Estradiol Hybrids.

Scott D. Kuduk, Fuzhong F. Zheng, Laura Sepp-Lorenzino, Neal Rosen, Samuel J. Danishefsky

Journal:

Year:

1999

File:

PDF, 30 KB

1999

8

ChemInform Abstract: Synthesis and Evaluation of Geldanamycin—Testosterone Hybrids.

Scott D. Kuduk, Christina R. Harris, Fuzhong F. Zheng, Laura Sepp-Lorenzino, Quathek Ouerfelli, Neal Rosen, Samuel J. Danishefsky

Journal:

Year:

2000

File:

PDF, 25 KB

2000

9

ChemInform Abstract: LY294002-Geldanamycin Heterodimers as Selective Inhibitors of the PI3K and PI3K-Related Family.

Gabriela Chiosis, Neal Rosen, Sepp-Lorenzino Sepp-Lorenzino

Journal:

Year:

2001

File:

PDF, 27 KB

2001

10

Expression of Micro-RNA-145 is regulated by a highly conserved genomic sequence 3′ to the pre-miR

Gaspare La Rocca, Bin Shi, Laura Sepp-Lorenzino, Renato Baserga

Journal:

Journal of Cellular Physiology

Year:

2011

Language:

english

File:

PDF, 366 KB

english, 2011

11

Synthesis and evaluation of geldanamycin–testosterone hybrids

Scott D Kuduk, Christina R Harris, Fuzhong F Zheng, Laura Sepp-Lorenzino, Quathek Ouerfelli, Neal Rosen, Samuel J Danishefsky

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 160 KB

english, 2000

12

LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family

Gabriela Chiosis, Neal Rosen, Laura Sepp-Lorenzino

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 152 KB

english, 2001

13

Synthesis and evaluation of geldanamycin-estradiol hybrids

Scott D. Kuduk, Fuzhong F. Zheng, Laura Sepp-Lorenzino, Neal Rosen, Samuel J. Danishefsky

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 339 KB

english, 1999

14

Isoprenylated Proteins in Myelin

Laura Sepp-Lorenzino, Peter S. Coleman, Jorge N. Larocca

Journal:

Journal of Neurochemistry

Year:

1994

Language:

english

File:

PDF, 720 KB

english, 1994

15

Farnesyltransferase inhibitors and anti-Ras therapy

Jackson B. Gibbs, Nancy E. Kohl, Kenneth S. Koblan, Charles A. Omer, Laura Sepp-Lorenzino, Neal Rosen, Neville J. Anthony, Michael W. Conner, S. Jane deSolms, Theresa M. Williams, Samuel L. Graham, Ge

Journal:

Breast Cancer Research and Treatment

Year:

1996

Language:

english

File:

PDF, 737 KB

english, 1996

16

A peptidomimetic inhibitor ofrasfunctionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility

F. M. Sirotnak, Laura Sepp-Lorenzino, Nancy E. Kohl, Neal Rosen, Howard I. Scher

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 102 KB

english, 2000

17

Analysis of the activating mutations within the activation loop of leukemia targets Flt-3 and c-Kit based on protein homology modeling

Maricel Torrent, Keith Rickert, Bo-Sheng Pan, Laura Sepp-Lorenzino

Journal:

Journal of Molecular Graphics and Modelling

Year:

2004

Language:

english

File:

PDF, 955 KB

english, 2004

18

Challenges and Opportunities for Local and Systemic Delivery of siRNA and Antisense Oligonucleotides

Sepp-Lorenzino, L, Ruddy, MK

Journal:

Clinical Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 207 KB

english, 2008

19

The microtubule-stabilizing agents epothilones A and B and their desoxy-derivatives induce mitotic arrest and apoptosis in human prostate cancer cells

Sepp-Lorenzino, L, Balog, A, Su, D-S, Meng, D, Timaul, N, Scher, H I, Danishefsky, S J, Rosen, N

Journal:

Prostate Cancer and Prostatic Diseases

Year:

1999

Language:

english

File:

PDF, 2.40 MB

english, 1999

20

Farnesyl:protein transferase inhibitors as potential agents for the management of human prostate cancer

Sepp-Lorenzino, L, Tjaden, G, Moasser, M M, Timaul, N, Ma, Z, Kohl, N E, Gibbs, J B, Oliff, A, Rosen, N, Scher, H I

Journal:

Prostate Cancer and Prostatic Diseases

Year:

2001

Language:

english

File:

PDF, 338 KB

english, 2001

21

Structure and function of the insulin-like growth factor I receptor

Laura Sepp-Lorenzino

Journal:

Breast Cancer Research and Treatment

Year:

1998

File:

PDF, 1.45 MB

1998

22

Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

Weikang Tao, Victoria J. South, Yun Zhang, Joseph P. Davide, Linda Farrell, Nancy E. Kohl, Laura Sepp-Lorenzino, Robert B. Lobell

Journal:

Year:

2005

Language:

english

File:

PDF, 667 KB

english, 2005

23

Cell-cycle-dependent, differential prenylation of proteins

Laura SEPP-LORENZINO, Srinivasa RAO, Peter S. COLEMAN

Journal:

Year:

1991

Language:

english

File:

PDF, 1.33 MB

english, 1991

24

Cellular distribution of cholesterogenesis-linked, phosphoisoprenylated proteins in proliferating cells

Laura Sepp-Lorenzino, Neal Azrolan, Peter S. Coleman

Journal:

Year:

1989

Language:

english

File:

PDF, 1.02 MB

english, 1989

25

Regulation of microRNA-145 by growth arrest and differentiation

Gaspare La Rocca, Bin Shi, Alessandra Audia, Giovanna Ferrari-Amorotti, Hestia S. Mellert, Bruno Calabretta, Steven B. McMahon, Laura Sepp-Lorenzino, Renato Baserga

Journal:

Experimental Cell Research

Year:

2011

Language:

english

File:

PDF, 1.25 MB

english, 2011

26

Total Synthesis of Spirotryprostatin A, Leading to the Discovery of Some Biologically Promising Analogues

Edmondson, Scott, Danishefsky, Samuel J., Sepp-Lorenzino, Laura, Rosen, Neal

Journal:

Journal of the American Chemical Society

Year:

1999

Language:

english

File:

PDF, 217 KB

english, 1999

27

Endosomolytic Bioreducible Poly(amido amine disulfide) Polymer Conjugates for the in Vivo Systemic Delivery of siRNA Therapeutics

Parmar, Rubina Giare, Busuek, Marina, Walsh, Eileen S., Leander, Karen R., Howell, Bonnie J., Sepp-Lorenzino, Laura, Kemp, Eric, Crocker, Louis S., Leone, Anthony, Kochansky, Christopher J., Carr, Bri

Journal:

Bioconjugate Chemistry

Year:

2013

Language:

english

File:

PDF, 342 KB

english, 2013

28

Expression of Asialoglycoprotein Receptor 1 in Human Hepatocellular Carcinoma

Shi, B., Abrams, M., Sepp-Lorenzino, L.

Journal:

Journal of Histochemistry & Cytochemistry

Year:

2013

Language:

english

File:

PDF, 1.19 MB

english, 2013

29

Pharmacologic Shifting of a Balance between Protein Refolding and Degradation Mediated by Hsp90

Christine Schneider, Laura Sepp-Lorenzino, Elmar Nimmesgern, Ouathek Ouerfelli, Samuel Danishefsky, Neal Rosen and F. Ulrich Hartl

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 1.63 MB

english, 1996

30

Farnesyl Transferase Inhibitors Cause Enhanced Mitotic Sensitivity to Taxol and Epothilones

Mark M. Moasser, Laura Sepp-Lorenzino, Nancy E. Kohl, Allen Oliff, Aaron Balog, Dai-Shi Su, Samuel J. Danishefsky and Neal Rosen

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.41 MB

english, 1998

31

A Concise Total Synthesis of Dysidiolide through Application of a Dioxolenium-Mediated Diels−Alder Reaction

Magnuson, Steven R., Sepp-Lorenzino, Laura, Rosen, Neal, Danishefsky, Samuel J.

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 74 KB

english, 1998

32

Total Synthesis of Tryprostatin B: Generation of a Nucleophilic Prenylating Species from a Prenylstannane

Depew, Kristopher M., Danishefsky, Samuel J., Rosen, Neal, Sepp-Lorenzino, Laura

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 101 KB

english, 1996

33

Antiangiogenic agents targeting vascular endothelial growth factor and its receptors in clinical development

Sepp-Lorenzino, Laura, Thomas, Kenneth A

Journal:

Expert Opinion on Investigational Drugs

Year:

2002

Language:

english

File:

PDF, 313 KB

english, 2002

34

A Single Dose of EGLN1 siRNA Yields Increased Erythropoiesis in Nonhuman Primates

Abrams, Marc T., Koser, Martin, Burchard, Julja, Strapps, Walter, Mehmet, Huseyin, Gindy, Marian, Zaller, Dennis, Sepp-Lorenzino, Laura, Stickens, Dominique

Journal:

Nucleic Acid Therapeutics (Formerly Oligonucleotides)

Year:

2014

Language:

english

File:

PDF, 577 KB

english, 2014

35

92nd Annual Meeting of the American Association for Cancer Research

Buser, Carolyn, Takaki, Tohru, Sepp-Lorenzino, Laura

Journal:

Expert Opinion on Investigational Drugs

Year:

2001

Language:

english

File:

PDF, 335 KB

english, 2001

36

[IEEE 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - San Diego, CA (2012.8.28-2012.9.1)] 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Quantification of Cy-5 siRNA signal in the intra-vital multi-photon microscopy images

Chen, A., Dogdas, B., Mehta, S., Haskell, K., Ng, B., Keough, E., Howell, B., Meacham, D. A., Aslamkhan, A. G., Davide, J., Stanton, M., Bagchi, A., Sepp-Lorenzino, L., Weikang Tao,

Year:

2012

Language:

english

File:

PDF, 990 KB

english, 2012

37

Prostate cancer: therapeutic patent review

Sepp-Lorenzino, Laura, Slovin, Susan

Journal:

Expert Opinion on Therapeutic Patents

Year:

2000

Language:

english

File:

PDF, 104 KB

english, 2000

38

A Novel Orally Bioavailable Inhibitor of Kinase Insert Domain-Containing Receptor Induces Antiangiogenic Effects and Prevents Tumor Growth in Vivo

Sepp-Lorenzino, L.

Journal:

Cancer Research

Year:

2004

Language:

english

File:

PDF, 275 KB

english, 2004

39

Pharmacokinetic/pharmacodynamic-based decision making in the development of MK-0888, a VEGFR-2/FLT-3 kinase inhibitor

Iwamoto, Marian, Friedman, Evan J., Sepp-Lorenzino, Laura, Talaty, Jennifer E., Agrawal, Nancy G. B., Wagner, John A.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2015

Language:

english

File:

PDF, 334 KB

english, 2015

40

A Farnesyl-Protein Transferase Inhibitor Induces p21 Expression and G1 Block in p53 Wild Type Tumor Cells

Sepp-Lorenzino, L., Rosen, N.

Journal:

Journal of Biological Chemistry

Year:

1998

Language:

english

File:

PDF, 1.19 MB

english, 1998

41

An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis

Tao, W., South, V. J., Diehl, R. E., Davide, J. P., Sepp-Lorenzino, L., Fraley, M. E., Arrington, K. L., Lobell, R. B.

Journal:

Molecular and Cellular Biology

Year:

2007

Language:

english

File:

PDF, 652 KB

english, 2007

42

Noninvasive Imaging of Lipid Nanoparticle–Mediated Systemic Delivery of Small-Interfering RNA to the Liver

Tao, Weikang, Davide, Joseph P, Cai, Mingmei, Zhang, Guo-Jun, South, Victoria J, Matter, Andrea, Ng, Bruce, Zhang, Ye, Sepp-Lorenzino, Laura

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 790 KB

english, 2010

43

Herbimycin A Induces the 20 S Proteasome- and Ubiquitindependent Degradation of Receptor Tyrosine Kinases

Sepp-Lorenzino, L., Ma, Z., Lebwohl, D. E., Vinitsky, A., Rosen, N.

Journal:

Journal of Biological Chemistry

Year:

1995

File:

PDF, 11.83 MB

1995

44

Micro RNA 145 Targets the Insulin Receptor Substrate-1 and Inhibits the Growth of Colon Cancer Cells

Shi, B., Sepp-Lorenzino, L., Prisco, M., Linsley, P., deAngelis, T., Baserga, R.

Journal:

Journal of Biological Chemistry

Year:

2007

Language:

english

File:

PDF, 853 KB

english, 2007

45

Quantitative evaluation of siRNA delivery in vivo

Pei, Y., Hancock, P. J., Zhang, H., Bartz, R., Cherrin, C., Innocent, N., Pomerantz, C. J., Seitzer, J., Koser, M. L., Abrams, M. T., Xu, Y., Kuklin, N. A., Burke, P. A., Sachs, A. B., Sepp-Lorenzino,

Journal:

Year:

2010

Language:

english

File:

PDF, 757 KB

english, 2010

46

Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery

Shi, B., Keough, E., Matter, A., Leander, K., Young, S., Carlini, E., Sachs, A. B., Tao, W., Abrams, M., Howell, B., Sepp-Lorenzino, L.

Journal:

Journal of Histochemistry & Cytochemistry

Year:

2011

Language:

english

File:

PDF, 10.43 MB

english, 2011

47

Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses

Tao, Weikang, Mao, Xianzhi, Davide, Joseph P, Ng, Bruce, Cai, Mingmei, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 249 KB

english, 2011

48

Immunohistochemical Detection of Antitumor, Antimetastasis, and Antiangiogenesis Effects of a Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor in an Orthotopic Breast Cancer Metastasis Model

Shi, Bin, Hardwick, James, Connolly, Brett, Mao, Xianzhi, McFall, Rosemary, Hill, Susan, Thomas, Kenneth A., Kohl, Nancy E., Sepp-Lorenzino, Laura

Journal:

Journal of Histotechnology

Year:

2010

Language:

english

File:

PDF, 2.41 MB

english, 2010

49

Growth inhibition by microRNAs that target the insulin receptor substrate-1

La Rocca, Gaspare, Shi, Bin, Badin, Margherita, De Angelis, Tiziana, Sepp-Lorenzino, Laura, Baserga, Renato

Journal:

Year:

2009

Language:

english

File:

PDF, 1.08 MB

english, 2009

50

Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth

Khan, Tayeba, Weber, Hans, DiMuzio, Jillian, Matter, Andrea, Dogdas, Belma, Shah, Tosha, Thankappan, Anil, Disa, Jyoti, Jadhav, Vasant, Lubbers, Laura, Sepp-Lorenzino, Laura, Strapps, Walter R, Tadin-

Journal:

Molecular Therapy — Nucleic Acids

Year:

2016

Language:

english

File:

PDF, 1.31 MB

english, 2016